Tyrosine is an amino acid that is beginning find a role in horse calming supplements. Unfortunately a number of the other amino acids used in calmers also begin with “T” creating a huge potential for confusion – especially as some of them work in particularly different ways.
Tyrosine is incorporated into many proteins and itself can be made in the body from phenylalanine. Animals can’t make phenylalanine so if they are not eating enough of that they can run out of tyrosine impacting on the ability to make proteins.
Tyrosine is also used to make a number of hormones and neurotransmitters. These include dopamine, epinephrine (also known as adrenaline) and norepinephrine. It is the broader biologically active chemicals – or the lack of them - that impact most on horse behaviour. When stressed horses produce more of these hormones that can deplete tyrosine (and tryptophan) levels. A shortage of those two amino acids seems to lead to insufficient levels in the brain and that is what causes the behavioural issues.
Supplementing with tyrosine does not seem to force the production of any of these hormones - so it has no effect if the levels have not been depleted (see below). So it meets our (EquiFeast’s) requirement of being an “enabler” not a drug. At EquiFeast we are passionate that our job is to help horse’s brains to function properly not to force them to be sedated. Having said that the combination of very low levels of tyrosine with high magnesium diets doesn’t seem to be ideal. So we do have a minimum application rate for tyrosine.
This showed up in the trials we ran on tyrosine early in 2019. The outcomes of those trials were roughly:
- 10% negative effect (with high Mg diets)
- 30% no effect
- 60% helped horses with improved behaviour
So, just as with any other calmer, it isn’t always the whole answer. During the first year of incorporating tyrosine into our chelated calcium products we have definitely had fewer fine tuning needs. So tyrosine has been an overwhelmingly successful improvement to our formulations. But we have found five horses (a miniscule percentage) that respond poorly to it - even with no added magnesium in the diet. These five ALL had what we might call hormone diseases (EMS, IR or PSSM). So while not all horses that have these problems respond badly to tyrosine it seems that all of the horses that do respond badly to tyrosine have one of these problems. We can't find any reference to this in the literature or any mentions from other supplement companies using tyrosine but if you Google "diabetes" and tyrosine you get some questions raised over human situations.
Our response to this is to make CoolCORE Mag FREE available both with and without tyrosine. All LamiCORE is tyrosine free. I am sure that our wonderful customers will continue to provide us with feedback that will enable us to understand this better and better over the next few years.
The really good news about tyrosine is that we seem to be able to use much smaller amounts than we have of Tryptophan in the past. It is also much more palatable than tryptophan. So tryptophan has been demoted in our fine tuning process and may become less important over time.
The other two amino acids beginning with “T” that are commonly used in calmers are Theanine and Taurine. We do not use either as both interfere with normal brain function by locking on to the same receptors in the brain as diazepam. This makes them non-compliant with FEI regulations as well as being a method of calming horses that we are not comfortable with.
EquiFeast products that contain Tyrosine.
This is a long list so feel free to contact us to chat about your horse by phone on 01453 836974 or email advice@EquiFeast.com:
Chelated calcium products that are available without Tyrosine:
Would you like us to take a look at your whole diet? Since we started diet reviews and encouraging customers and new recruits to stop using feeds with magnesium or GABA agonist herbs in them our success rates and retention rates have improved dramatically.